Article
A targeting motif involved in sodium channel clustering at the axonal initial segment.
Science (New York, N.Y.) - 27 Jun 2003
Garrido Juan José, Giraud Pierre, Carlier Edmond, Fernandes Fanny, Moussif Anissa, Fache Marie-Pierre, Debanne Dominique, Dargent Bénédicte
Abstract excerpt
The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Nav1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Nav1.2II-III linker protein led to the disorganization of...
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