Article
Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization.
Neuron - 5 Jun 2003
Saito Fumiaki, Moore Steven A, Barresi Rita, Henry Michael D, Messing Albee, Ross-Barta Susan E, Cohn Ronald D, Williamson Roger A, Sluka Kathleen A, Sherman Diane L, Brophy Peter J, Schmelzer James D, Low Phillip A, Wrabetz Lawrence, Feltri M Laura, Campbell Kevin P
Abstract excerpt
Dystroglycan is a central component of the dystrophin-glycoprotein complex implicated in the pathogenesis of several neuromuscular diseases. Although dystroglycan is expressed by Schwann cells, its normal peripheral nerve functions are unknown. Here we show that selective deletion of Schwann cell dystroglycan results in slowed nerve conduction and nodal changes including reduced sodium channel density and...
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