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Article

Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression.

Psychoneuroendocrinology - 1 Mar 2017

Ancelin Marie-Laure, Scali Jacqueline, Norton Joanna, Ritchie Karen, Dupuy Anne-Marie, Chaudieu Isabelle, Ryan Joanne

Abstract excerpt

Variability in the serotonin transporter (5-HTTLPR) gene can influence the risk of depression associated with adversity, as well as cortisol stress reactivity, although not consistently. No study has examined the impact of both a stressful environment and corticotropic-axis dysfunction on depression, as a function of 5-HTTLPR. This population-based study included 334 subjects aged 65 and older. Depression was...

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PMID: 28024274
DOI: 10.1016/j.psyneuen.2016.11.016

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