Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis

1 Sept 2003

Abstract excerpt

Meningitis occurs when blood-borne pathogens cross the blood-brain barrier (BBB) in a complex interplay between endothelial cells and microbial gene products. We sought to understand the initial response of the BBB to the human meningeal pathogen group B Streptococcus (GBS) and the organism's major virulence factors, the exopolysaccharide capsule and the beta-hemolysin/cytolysin toxin (beta-h/c). Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections and Vaccines
Share to Neonatal and Maternal Infections
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12952922
DOI: 10.1172/jci17335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitisPMID 12952922Read ↗

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitisSemantic proximity Read ↗

Regulation of CovR expression in Group B Streptococcus impacts blood–brain barrier penetrationSemantic proximity Read ↗

Global Changes in Staphylococcus aureus Gene Expression in Human BloodSemantic proximity Read ↗

Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis.Semantic proximity Read ↗

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acidSemantic proximity Read ↗

The CiaR Response Regulator in Group B<i>Streptococcus</i>Promotes Intracellular Survival and Resistance to Innate Immune DefensesSemantic proximity Read ↗

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitisSemantic proximity Read ↗

Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.Semantic proximity Read ↗

Understanding the Regulation of Group B Streptococcal Virulence FactorsSemantic proximity Read ↗

Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signalingSemantic proximity Read ↗

Cerebrospinal fluid inflammome analysis identifies host- and pathogen-specific inflammatory profiles and signaling pathways in meningitis and predicts clinical outcomeSemantic proximity Read ↗

Peripheral blood vessels are a niche for blood-borne meningococciSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.