Article

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis

2003-09-01

Abstract excerpt

Meningitis occurs when blood-borne pathogens cross the blood-brain barrier (BBB) in a complex interplay between endothelial cells and microbial gene products. We sought to understand the initial response of the BBB to the human meningeal pathogen group B Streptococcus (GBS) and the organism’s major virulence factors, the exopolysaccharide capsule and the β-hemolysin/cytolysin toxin (β-h/c). Using oligonucleotide m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38227037-1deb-5cba-97f7-cbd6c3ff3c39
DOI: 10.1172/jci200317335

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitisDOI 10.1172/jci200317335Read

Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitisSemantic proximity Read

Regulation of CovR expression in Group B Streptococcus impacts blood–brain barrier penetrationSemantic proximity Read

Global Changes in Staphylococcus aureus Gene Expression in Human BloodSemantic proximity Read

Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.Semantic proximity Read

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acidSemantic proximity Read

The CiaR Response Regulator in Group B<i>Streptococcus</i>Promotes Intracellular Survival and Resistance to Innate Immune DefensesSemantic proximity Read

Identification of a group B streptococcal fibronectin binding protein, SfbA, that contributes to invasion of brain endothelium and development of meningitis.Semantic proximity Read

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitisSemantic proximity Read

Meningitic Escherichia coli α-hemolysin aggravates blood–brain barrier disruption via targeting TGFβ1-triggered hedgehog signalingSemantic proximity Read

Understanding the Regulation of Group B Streptococcal Virulence FactorsSemantic proximity Read

Group B <i>Streptococcus</i> drives major transcriptomic changes in the colonic epitheliumSemantic proximity Read

Interaction of Streptococcus agalactiae and Cellular Innate Immunity in Colonization and DiseaseSemantic proximity Read