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Genetic analysis of polynucleotide phosphorylase structure and functions.

Biochimie - 1 Jan 2007

Briani Federica, Del Favero Marta, Capizzuto Rossana, Consonni Chiara, Zangrossi Sandro, Greco Claudio, De Gioia Luca, Tortora Paolo, Dehò Gianni

Abstract excerpt

Polynucleotide phosphorylase (PNPase) is a phosphate-dependent 3' to 5' exonuclease widely diffused among bacteria and eukaryotes. The enzyme, a homotrimer, can also be found associated with the endonuclease RNase E and other proteins in a heteromultimeric complex, the RNA degradosome. PNPase negatively controls its own gene (pnp) expression by destabilizing pnp mRNA. A current model of autoregulation maintains...

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Identifiers

PMID: 17084501
DOI: 10.1016/j.biochi.2006.09.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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