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Article

Isolation of a ribozyme with 5'-5' ligase activity.

Chemistry & biology - 1 May 1995

Chapman K B, Szostak J W

Abstract excerpt

BACKGROUND: Many new ribozymes, including sequence-specific nucleases, ligases and kinases, have been isolated by in vitro selection from large pools of random-sequence RNAs. We are attempting to use in vitro selection to isolate new ribozymes that have, or can be evolved to have, RNA polymerase-like activities. As phosphorimidazolide-activated nucleosides are extensively used to study non-enzymatic RNA...

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Source

Identifiers

PMID: 9383434
DOI: 10.1016/1074-5521(95)90051-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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