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Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro

1 Jul 2012

Abstract excerpt

The micronutrients folate and selenium may modulate DNA methylation patterns by affecting intracellular levels of the methyl donor S-adenosylmethionine (SAM) and/or the product of methylation reactions S-adenosylhomocysteine (SAH). WI-38 fibroblasts and FHC colon epithelial cells were cultured in the presence of two forms of folate or four forms of selenium at physiologically-relevant doses, and their effects on...

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PMID: 22617627
DOI: 10.4161/epi.20461

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