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The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines

13 Mar 2015

Abstract excerpt

Folate and its synthetic form, folic acid (FA), are essential vitamins for the regeneration of S-adenosyl methionine molecules, thereby maintaining adequate cellular methylation. The deregulation of DNA methylation is a contributing factor to carcinogenesis, as alterations in genetic methylation may contribute to stem cell reprogramming and dedifferentiation processes that lead to a cancer stem cell (CSC)...

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PMID: 25804133
DOI: 10.1016/j.jnutbio.2015.02.002

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