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Article

Relative Distribution of Folate Species Is Associated with Global DNA Methylation in Human Colorectal Mucosa

20 May 2012

Abstract excerpt

Folate exists as functionally diverse species within cells. Although folate deficiency may contribute to DNA hypomethylation in colorectal cancer, findings on the association between total folate concentration and global DNA methylation have been inconsistent. This study determined global, LINE-1, and Alu DNA methylation in blood and colon of healthy and colorectal cancer patients and their relationship to folate...

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Share to Epigenetics and DNA Methylation
Share to Folate and B Vitamins Research
Share to Genetic factors in colorectal cancer

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PMID: 22609762
DOI: 10.1158/1940-6207.capr-11-0577

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