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Article

Effects of CYP induction by rifampicin on tamoxifen exposure.

Clinical pharmacology and therapeutics - 1 Jul 2012

Binkhorst L, van Gelder T, Loos W J, de Jongh F E, Hamberg P, Moghaddam-Helmantel I M Ghobadi, de Jonge E, Jager A, Seynaeve C, van Schaik R H N, Verweij J, Mathijssen R H J

Abstract excerpt

Tamoxifen undergoes biotransformation into several metabolites, including endoxifen. Differences in metabolism contribute to the interindividual variability in endoxifen concentrations, potentially affecting treatment efficacy. We evaluated the effects of cytochrome P450 (CYP) induction by rifampicin on the exposure levels of tamoxifen and its metabolites and found that coadministration of rifampicin resulted in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22617226
DOI: 10.1038/clpt.2011.372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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