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Article

Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity.

British journal of clinical pharmacology - 1 Jan 2004

Coller Janet K, Krebsfaenger Niels, Klein Kathrin, Wolbold Renzo, Nüssler Andreas, Neuhaus Peter, Zanger Ulrich M, Eichelbaum Michel, Mürdter Thomas E

Abstract excerpt

AIMS: To characterize the interindividual variability and the individual CYP involved in the formation of alpha-hydroxy-, N-desmethyl- and N-didesmethyl-tamoxifen from tamoxifen. METHODS: Microsomes from 50 human livers were used to characterize the interindividual variability in the alpha-hydroxylation, N-desmethylation and N-didesmethylation of tamoxifen. Selective inhibitors and recombinant enzymes were used...

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Identifiers

PMID: 14678348
DOI: 10.1046/j.1365-2125.2003.01970.x
PMCID: PMC1884410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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