Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.

doi:10.1093/carcin/15.12.2733

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Article

Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.

Carcinogenesis - 1 Dec 1994

Williams M L, Lennard M S, Martin I J, Tucker G T

Abstract excerpt

Tamoxifen and its metabolite 4-hydroxytamoxifen can both exist as geometrical isomers. Trans-tamoxifen is an oestrogen receptor antagonist and is used for the treatment of breast cancer. Trans-4-hydroxytamoxifen is 100 times more anti-oestrogenic than trans-tamoxifen. The cis isomers of tamoxifen...

Topics

Adult
Biotransformation
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Drug Resistance
Female
Genetic Variation
Humans
Isomerism
Ketoconazole
Male
Microsomes, Liver
Middle Aged
NADP
Proadifen
Tamoxifen

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