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Article

Rifampicin markedly decreases the exposure to oral and intravenous tramadol.

European journal of clinical pharmacology - 1 Jun 2013

Saarikoski Tuukka, Saari Teijo I, Hagelberg Nora M, Neuvonen Mikko, Neuvonen Pertti J, Scheinin Mika, Olkkola Klaus T, Laine Kari

Abstract excerpt

PURPOSE: Tramadol is mainly metabolized by the cytochrome P450 (CYP) 2D6, CYP2B6 and CYP3A4 enzymes. The aim of this study was to evaluate the effect of enzyme induction with rifampicin on the pharmacokinetics and pharmacodynamics of oral and intravenous tramadol. METHODS: This was a randomized p...

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Source

Identifiers

PMID: 23242004
DOI: 10.1007/s00228-012-1460-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23242004-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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