Article
The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity.
Therapeutic drug monitoring - 1 Aug 2015
Welzen Marieke E B, Dezentjé Vincent O, van Schaik Ron H N, Colbers Angela P H, Guchelaar Henk-Jan, van Erp Nielka P, den Hartigh Jan, Burger David M, van Laarhoven Hanneke W M
Abstract excerpt
BACKGROUND: The effect of tamoxifen dose elevation on endoxifen serum concentration was investigated in patients with reduced CYP2D6 activity resulting from genetic variation and/or CYP2D6 inhibitor use. Additionally, baseline differences in endoxifen concentrations between the different CYP2D6 phenotypes were studied. METHODS: Patients, treated with tamoxifen 20 mg once daily (QD) for at least 4 weeks, were...
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