Article
Fast and Adequate Liquid Chromatography-Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring.
Therapeutic drug monitoring - 1 Apr 2017
de Krou Sven, Rosing Hilde, Nuijen Bastiaan, Schellens Jan H M, Beijnen Jos H
Abstract excerpt
BACKGROUND: Z-endoxifen (further referred to as endoxifen, unless stated otherwise) is proposed as the most important metabolite of tamoxifen. Patients receiving adjuvant tamoxifen treatment with endoxifen levels below the threshold of 5.9 ng/mL may have an increased risk of breast cancer recurrence. Several factors, such as genetic polymorphisms, drug interactions, and (non)adherence, lead to large interpatient...
Topics
Join the communities discussing this publication.