Article
Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death.
Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011
Schuenemann Verena J, Bos Kirsten, DeWitte Sharon, Schmedes Sarah, Jamieson Joslyn, Mittnik Alissa, Forrest Stephen, Coombes Brian K, Wood James W, Earn David J D, White William, Krause Johannes, Poinar Hendrik N
Abstract excerpt
Although investigations of medieval plague victims have identified Yersinia pestis as the putative etiologic agent of the pandemic, methodological limitations have prevented large-scale genomic investigations to evaluate changes in the pathogen's virulence over time. We screened over 100 skeletal remains from Black Death victims of the East Smithfield mass burial site (1348-1350, London, England). Recent methods...
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