Article
Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients.
Surgery - 1 Mar 2009
Lo Su-Shun, Chen Jen-Hao, Wu Chew-Wun, Lui Win-Yiu
Abstract excerpt
BACKGROUND: Activated nuclear factor-kappaB (NF-kappaB) is associated reportedly with the pathogenesis of numerous malignancies. This study investigated whether a common insertion (ins)/deletion (del) polymorphism (-94 ins/del ATTG) in the NFKB1 promoter is associated with susceptibility to gastric cancer and its tumor behavior. METHODS: Blood samples from 182 gastric cancer patients and 116 controls were...
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