Article
FTO expression is regulated by availability of essential amino acids.
International journal of obesity (2005) - 1 May 2013
Cheung M K, Gulati P, O'Rahilly S, Yeo G S H
Abstract excerpt
Genome-wide association studies have revealed that single nucleotide polymorphisms in fat mass and obesity-associated transcript (FTO) are robustly associated with body mass index and obesity. Expression of Fto in the hypothalamic arcuate nucleus is bidirectionally regulated as a function of nutritional status; decreasing following a 48-h fast and increasing after 10-week exposure to a high-fat diet. Here, we...
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