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Molecular prosthetics and CFTR modulators additively increase secretory HCO 3 − flux in cystic fibrosis airway epithelia

2025-06-24

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<h4>ABSTRACT</h4> Cystic Fibrosis (CF) is caused by loss-of-function mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel predominantly expressed on the apical membrane of epithelial cells. Reduced Cl − and HCO 3 − secretion due to dysfunctional CFTR results in a decrease in lung function and is the leading cause of morbidity in individuals with CF. Rec...

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Literature Corpus work: 7d08f031-4871-55e4-9ed6-ad05de110491
DOI: 10.1101/2025.06.18.660463

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Molecular prosthetics and CFTR modulators additively increase secretory HCO <sub>3</sub> <sup>−</sup> flux in cystic fibrosis airway epithelia

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