Article
A small molecule CFTR potentiator restores ATP-dependent channel gating to the cystic fibrosis mutant G551D-CFTR.
British journal of pharmacology - 1 Apr 2022
Liu Jia, Berg Allison P, Wang Yiting, Jantarajit Walailak, Sutcliffe Katy J, Stevens Edward B, Cao Lishuang, Pregel Marko J, Sheppard David N
Abstract excerpt
BACKGROUND AND PURPOSE: Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators are small molecules developed to treat the genetic disease cystic fibrosis (CF). They interact directly with CFTR Cl- channels at the plasma membrane to enhance channel gating. Here, we investigate the action of a new CFTR potentiator, CP-628006 with a distinct chemical structure. EXPERIMENTAL APPROACH: Using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.