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Article

Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.

The Journal of general physiology - 1 Dec 2003

Gong Xiandi, Linsdell Paul

Abstract excerpt

Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO2)42- acts as an impermeant voltage-dependent blocker of the CFTR pore when added to the intracellular face of excised membrane patches. Block was of modest affinity (apparent Kd 556 microM),...

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Identifiers

PMID: 14610019
DOI: 10.1085/jgp.200308889
PMCID: PMC2229596

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.PMID 14610019Read ↗

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Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.Semantic proximity Read ↗

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Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore.Semantic proximity Read ↗

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