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Article

Trivalent anions as probes of the CFTR channel pore.

General physiology and biophysics - 1 May 2024

Linsdell Paul

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel uses positively charged amino-acid side-chains to form binding sites for permeating anions. These binding sites have been investigated experimentally using a number of anionic probes. Mutations that alter the distribution of positive and negative charges within the pore have differential effects on the binding of monovalent versus divalent...

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Identifiers

PMID: 38774920
DOI: 10.4149/gpb_2024007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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