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Article

ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components.

Endocrine-related cancer - 1 Jun 2005

Martineti Valentina, Picariello Lucia, Tognarini Isabella, Carbonell Sala Silvia, Gozzini Alessia, Azzari Chiara, Mavilia Carmelo, Tanini Annalisa, Falchetti Alberto, Fiorelli Gianna, Tonelli Francesco, Brandi Maria Luisa

Abstract excerpt

Several strands of evidence indicate that oestrogens exert a protective role against the development of colon cancer through indirect and direct effects on colonic epithelium. Oestrogen receptor beta (ERbeta), the predominant ER subtype in human colon, is significantly decreased in colonic tumours compared with normal mucosa suggesting a potential role in the regulation of colon tumour growth. To investigate this...

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Identifiers

PMID: 15947116
DOI: 10.1677/erc.1.00861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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