Article
Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies.
Genome research - 1 Mar 2008
Gregorová Sona, Divina Petr, Storchova Radka, Trachtulec Zdenek, Fotopulosova Vladana, Svenson Karen L, Donahue Leah Rae, Paigen Beverly, Forejt Jiri
Abstract excerpt
Consomic (chromosome substitution) strains (CSs) represent the most recent addition to the mouse genetic resources aimed to genetically analyze complex trait loci (QTLs). In this study, we report the development of a set of 28 mouse intersubspecific CSs. In each CS, we replaced a single chromosome of the C57BL/6J (B6) inbred strain (mostly Mus m. domesticus) with its homolog from the PWD/Ph inbred strain of the...
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