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Article

Facilitating Complex Trait Analysis via Reduced Complexity Crosses.

Trends in genetics : TIG - 1 Aug 2020

Bryant Camron D, Smith Desmond J, Kantak Kathleen M, Nowak Thaddeus S, Williams Robert W, Damaj M Imad, Redei Eva E, Chen Hao, Mulligan Megan K

Abstract excerpt

Genetically diverse inbred strains are frequently used in quantitative trait mapping to identify sequence variants underlying trait variation. Poor locus resolution and high genetic complexity impede variant discovery. As a solution, we explore reduced complexity crosses (RCCs) between phenotypically divergent, yet genetically similar, rodent substrains. RCCs accelerate functional variant discovery via decreasing...

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Topics

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Share to Chromosomes, Mammalian
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Genotype

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Rodentia

Source

Open in PubMed Open full text

Identifiers

PMID: 32482413
DOI: 10.1016/j.tig.2020.05.003
PMCID: PMC7365571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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