Article
Identification of cis-regulatory variation influencing protein abundance levels in human plasma.
Human molecular genetics - 15 Aug 2012
Lourdusamy Anbarasu, Newhouse Stephan, Lunnon Katie, Proitsi Petra, Powell John, Hodges Angela, Nelson Sally K, Stewart Alex, Williams Stephen, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Lovestone Simon, Dobson Richard
Abstract excerpt
Proteins are central to almost all cellular processes, and dysregulation of expression and function is associated with a range of disorders. A number of studies in human have recently shown that genetic factors significantly contribute gene expression variation. In contrast, very little is known about the genetic basis of variation in protein abundance in man. Here, we assayed the abundance levels of proteins in...
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