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Article

Identification of NPMc+ acute myeloid leukemia in bone marrow smears.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2013

Bedekovics Judit, Rejtő László, Telek Béla, Kiss Attila, Hevessy Zsuzsanna, Ujfalusi Anikó, Méhes Gábor

Abstract excerpt

The most frequent genetic change currently known in acute myeloid leukemia (AML) is the mutation of the nucleophosmin (NPM) gene. Aberrant cytoplasmic accumulation of NPM protein (NPMc+) is the result of this mutation, and it can be demonstrated by immunohistochemistry for the identification of a favorable subgroup within "AML with normal karyotype" according to the World Health Organization classification. NPM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22595947
DOI: 10.1097/PAI.0b013e318256da37

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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