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Article

Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin.

Leukemia - 1 Oct 2005

Quentmeier H, Martelli M P, Dirks W G, Bolli N, Liso A, Macleod R A F, Nicoletti I, Mannucci R, Pucciarini A, Bigerna B, Martelli M F, Mecucci C, Drexler H G, Falini B

Abstract excerpt

We recently identified a new acute myeloid leukemia (AML) subtype characterized by mutations at exon-12 of the nucleophosmin (NPM) gene and aberrant cytoplasmic expression of NPM protein (NPMc+). NPMc+ AML accounts for about 35% of adult AML and it is associated with normal karyotype, wide morpho...

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Share to Antigens, CD34
Share to Cytoplasm
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Promyelocytic, Acute

Share to Mice, Inbred NOD

Share to Mice, SCID

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Source

Identifiers

PMID: 16079892
DOI: 10.1038/sj.leu.2403899

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16079892-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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