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Article

Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis.

Developmental biology - 1 Aug 2012

Woznica Arielle, Haeussler Maximilian, Starobinska Ella, Jemmett Jessica, Li Younan, Mount David, Davidson Brad

Abstract excerpt

The complex, partially redundant gene regulatory architecture underlying vertebrate heart formation has been difficult to characterize. Here, we dissect the primary cardiac gene regulatory network in the invertebrate chordate, Ciona intestinalis. The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase (FGF/MapK) activation of the transcription factor Ets1/2 (Ets). Through...

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Identifiers

PMID: 22595514
DOI: 10.1016/j.ydbio.2012.05.002
PMCID: PMC3383925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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