Gene regulatory networks in the evolution and development of the heart.

doi:10.1126/science.1132292

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Article

Gene regulatory networks in the evolution and development of the heart.

Science (New York, N.Y.) - 29 Sept 2006

Olson Eric N

Abstract excerpt

The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded...

Topics

Animals
Biological Evolution
Drosophila
Gene Duplication
Gene Expression Regulation, Developmental
Heart
Heart Defects, Congenital
Humans
Morphogenesis
Mutation
Regulatory Sequences, Nucleic Acid
Signal Transduction
Transcription Factors
Vertebrates

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Identifiers

PMID: 17008524
DOI: 10.1126/science.1132292
PMCID: PMC4459601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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