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Article

Gene regulatory networks in the evolution and development of the heart.

Science (New York, N.Y.) - 29 Sept 2006

Olson Eric N

Abstract excerpt

The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded...

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Share to Drosophila
Share to Gene Duplication
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 17008524
DOI: 10.1126/science.1132292
PMCID: PMC4459601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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