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Article

Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism.

American journal of respiratory and critical care medicine - 1 Dec 2005

Plant Barry J, Gallagher Charles G, Bucala Richard, Baugh John A, Chappell Sally, Morgan Linda, O'Connor Clare M, Morgan Kevin, Donnelly Seamas C

Abstract excerpt

RATIONALE: Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. It contributes toward an exaggerated gram-negative inflammatory response via its ability to induce Toll-like receptor-4 expression. Studies have shown that MIF knockout mice have less aggressive Pseudomonas infection (compared with wild-type). OBJECTIVES: To assess whether a novel functional MIF polymorphism was associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16179637
DOI: 10.1164/rccm.200412-1714OC

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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