Article
New microbicidal functions of tracheal glands: defective anti-infectious response to Pseudomonas aeruginosa in cystic fibrosis.
PloS one - 1 Jan 2009
Bastonero Sonia, Le Priol Yannick, Armand Martine, Bernard Christophe S, Reynaud-Gaubert Martine, Olive Daniel, Parzy Daniel, de Bentzmann Sophie, Capo Christian, Mege Jean-Louis
Abstract excerpt
Tracheal glands (TG) may play a specific role in the pathogenesis of cystic fibrosis (CF), a disease due to mutations in the cftr gene and characterized by airway inflammation and Pseudomonas aeruginosa infection. We compared the gene expression of wild-type TG cells and TG cells with the cftr DeltaF508 mutation (CF-TG cells) using microarrays covering the whole human genome. In the absence of infection, CF-TG...
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