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Article

Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.

Haematologica - 1 Feb 2018

Savola Paula, Brück Oscar, Olson Thomas, Kelkka Tiina, Kauppi Markku J, Kovanen Panu E, Kytölä Soili, Sokka-Isler Tuulikki, Loughran Thomas P, Leirisalo-Repo Marjatta, Mustjoki Satu

Abstract excerpt

Felty syndrome is a rare disease defined by neutropenia, splenomegaly, and rheumatoid arthritis. Sometimes the differential diagnosis between Felty syndrome and large granular lymphocyte leukemia is problematic. Recently, somatic STAT3 and STAT5B mutations were discovered in 30-40% of patients with large granular lymphocyte leukemia. Herein, we aimed to study whether these mutations can also be detected in Felty...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Large Granular Lymphocytic

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Source

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Identifiers

PMID: 29217783
DOI: 10.3324/haematol.2017.175729
PMCID: PMC5792275

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.PMID 29217783Read ↗

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