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Article

MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma.

Science signaling - 15 May 2012

Wood Kris C, Konieczkowski David J, Johannessen Cory M, Boehm Jesse S, Tamayo Pablo, Botvinnik Olga B, Mesirov Jill P, Hahn William C, Root David E, Garraway Levi A, Sabatini David M

Abstract excerpt

Cell microarrays are a promising tool for performing large-scale functional genomic screening in mammalian cells at reasonable cost, but owing to technical limitations they have been restricted for use with a narrow range of cell lines and short-term assays. Here, we describe MicroSCALE (Microarrays of Spatially Confined Adhesive Lentiviral Features), a cell microarray-based platform that enables application of...

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Identifiers

PMID: 22589389
DOI: 10.1126/scisignal.2002612
PMCID: PMC3498828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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