Article

A functional pre-screening platform for identifying points of vulnerability in the cell death map of human melanoma tumors

2020-11-11

Abstract excerpt

Targeted drug therapy in melanoma patients carrying the BRAF V600E mutation provides temporary remission, often followed by relapse due to acquired drug resistance. Here we propose a functional approach to circumvent drug resistance by applying a personalized prescreening platform that maps points of vulnerability in each tumor, prior to drug treatment. This platform applies siRNAs targeting 81 apoptosis, autopha...

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Literature Corpus work: ea849a5c-a53b-5193-b01e-56ddfc22b0fd
DOI: 10.1101/2020.11.11.377671

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