Article

Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy

2022-02-19

Abstract excerpt

Therapeutic approaches to treat melanoma include small molecule drugs that target activating protein mutations in pro-growth signaling pathways like the MAPK pathway. While beneficial to the approximately 50% of patients with activating BRAF V600 mutation, mono- and combination therapy with MAPK inhibitors is ultimately associated with acquired resistance. To better characterize the mechanisms of MAPK inhibitor r...

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Literature Corpus work: 890a212e-5caa-5f82-b764-e52f1258e7da
DOI: 10.1101/2022.02.15.480454

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