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Article

The apoptosis pathway and the genetic predisposition to Achilles tendinopathy.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2012

Nell Erica-Mari, van der Merwe Lize, Cook Jill, Handley Christopher J, Collins Malcolm, September Alison V

Abstract excerpt

Achilles tendinopathy (AT) is a degenerative condition for which several risk factors have been implicated including components of the inflammatory pathway. The aim was to assess functional variants within genes encoding components of the apoptosis signaling cascade and the effectiveness of a polygenic apoptosis profile to capture tendinopathy (TEN) risk. A total of 358 unaffected control (CON) participants [159...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22588838
DOI: 10.1002/jor.22144

Genes

CASP8
NOS2
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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