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Article

Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study.

Journal of science and medicine in sport - 1 Nov 2013

El Khoury Louis, Posthumus Michael, Collins Malcolm, Handley Christopher J, Cook Jill, Raleigh Stuart M

Abstract excerpt

OBJECTIVES: Achilles tendon pathology (ATP) is a multifactorial condition for which genetic risk factors have been identified. The ADAMTS, ADAM12 and TIMP2 genes encode enzymes that are important regulators of tendon homeostasis. ADAMTS2 and ADAMTS14 proteins are procollagen N-propeptidases for pro-collagen type I, type II, and type III. ADAMTS2, like COL5A1, has been linked to Ehlers-Danlos syndrome. Variants...

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Source

Identifiers

PMID: 23491141
DOI: 10.1016/j.jsams.2013.02.006

Genes

TIMP2
ADAMTS14
ADAM12
ADAMTS2
ADAMTS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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