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Article

Emergence of novel functions in transcriptional regulators by regression to stem protein types.

Molecular microbiology - 1 Aug 2007

Galvão Teca Calcagno, Mencía Mario, de Lorenzo Víctor

Abstract excerpt

Evolutionary expansion of metabolic networks entails the emergence of regulatory factors that become sensitive to new chemical species. A dedicated genetic system was developed for the soil bacterium Pseudomonas putida aimed at deciphering the steps involved in the gain of responsiveness of the toluene-activated prokaryotic regulator XylR to the xenobiotic chemical 2,4 dinitrotoluene (DNT). A mutant library of...

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PMID: 17645451
DOI: 10.1111/j.1365-2958.2007.05832.x

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Emergence of novel functions in transcriptional regulators by regression to stem protein types.PMID 17645451Read ↗

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