Article
Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance.
Nucleic acids research - 1 Apr 2012
Gaballa Ahmed, MacLellan Shawn, Helmann John D
Abstract excerpt
Bacterial transcription factors often function as DNA-binding proteins that selectively activate or repress promoters, although the biochemical mechanisms vary. In most well-understood examples, activators function by either increasing the affinity of RNA polymerase (RNAP) for the target promoter, or by increasing the isomerization of the initial closed complex to the open complex. We report that Bacillus...
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