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Article

A la carte transcriptional regulators: unlocking responses of the prokaryotic enhancer-binding protein XylR to non-natural effectors.

Molecular microbiology - 1 Oct 2001

Garmendia J, Devos D, Valencia A, de Lorenzo V

Abstract excerpt

To investigate the activation mechanism of the enhancer-binding protein XylR encoded by the TOL plasmid of Pseudomonas putida mt-2, a combinatorial library was generated composed of shuffled N-terminal A domains of the homologous regulators DmpR, XylR and TbuT, reassembled within the XylR structure. When the library was screened in vivo for responsiveness to non-effectors bulkier than one aromatic ring (such as...

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Source

Identifiers

PMID: 11679066
DOI: 10.1046/j.1365-2958.2001.02633.x

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