Article
Semiparametric maximum likelihood methods for analyzing genetic and environmental effects with case-control mother-child pair data.
Biometrics - 1 Sept 2012
Chen Jinbo, Lin Dongyu, Hochner Hagit
Abstract excerpt
Case-control mother-child pair design represents a unique advantage for dissecting genetic susceptibility of complex traits because it allows the assessment of both maternal and offspring genetic compositions. This design has been widely adopted in studies of obstetric complications and neonatal outcomes. In this work, we developed an efficient statistical method for evaluating joint genetic and environmental...
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