Semiparametric odds ratio model for case-control and matched case-control designs.

Abstract excerpt

We propose a semiparametric odds ratio model that extends Umbach and Weinberg's approach to exploiting gene-environment association model for efficiency gains in case-control designs to both discrete and continuous data. We directly model the gene-environment association in the control population to avoid estimating the intercept in the disease risk model, which is inherently difficult because of the scarcity of...

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