Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma.

doi:10.1186/1471-2407-12-177

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Article

Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma.

BMC cancer - 15 May 2012

Cardin Romilda, Romilda Cardin, Piciocchi Marika, Marika Piciocchi, Sinigaglia Alessandro, Alessandro Sinigaglia, Lavezzo Enrico, Enrico Lavezzo, Bortolami Marina, Marina Bortolami, Kotsafti Andromachi, Andromachi Kotsafti, Cillo Umberto, Umberto Cillo, Zanus Giacomo, Giacomo Zanus, Mescoli Claudia, Claudia Mescoli, Rugge Massimo, Massimo Rugge, Farinati Fabio, Fabio Farinati

Abstract excerpt

BACKGROUND: MicroRNAs expression has been extensively studied in hepatocellular carcinoma but little is known regarding the relationship, if any, with inflammation, production of reactive oxygen species (ROS), host's repair mechanisms and cell immortalization. This study aimed at assessing the extent of oxidative DNA damage (8-hydroxydeoxyguanosine - 8-OHdG) in different phases of the carcinogenetic process, in...

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PMID: 22587342
DOI: 10.1186/1471-2407-12-177
PMCID: PMC3420318

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