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Article

Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line

1 Oct 1997

Abstract excerpt

Cholangiocarcinoma is a malignant neoplasm originating from cholangiocytes. The mechanisms responsible for oncogenesis of cholangiocytes are unknown. Resistance to apoptosis, especially by altered expression of B-cell lymphoma/leukemia 2 (Bcl-2) family members, has been implicated as a mechanism contributing to malignant transformation. Thus, our aim was to test the hypothesis that altered expression of Bcl-2...

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PMID: 9328309
DOI: 10.1002/hep.510260413

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