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Article

Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012

Abe Haruka, Okazawa Makoto, Nakanishi Shigetada

Abstract excerpt

In maturing postnatal cerebellar granule cells, the Etv1/Er81 transcription factor is induced by sequential activity-dependent mechanisms through stimulation of AMPA and NMDA receptors, voltage-dependent Nav1.2 Na(+) channels, and voltage-dependent Ca(2+) channels. Etv1 then up-regulates a battery of maturation genes involved in the cerebellar circuitry. In this process, BDNF is also induced and participates in...

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Identifiers

PMID: 22586091
DOI: 10.1073/pnas.1206418109
PMCID: PMC3365191

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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