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Article

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac.

Journal of cellular physiology - 1 Dec 2017

Bustos Fernando J, Jury Nur, Martinez Pablo, Ampuero Estibaliz, Campos Matias, Abarzúa Sebastian, Jaramillo Karen, Ibing Susanne, Mardones Muriel D, Haensgen Henny, Kzhyshkowska Julia, Tevy Maria Florencia, Neve Rachael, Sanhueza Magdalena, Varela-Nallar Lorena, Montecino Martín, van Zundert Brigitte

Abstract excerpt

Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and promote plasticity, NR1NR2A receptors are mainly expressed in mature neurons and induce circuit stability. How the different subunits regulate these processes is unclear, but this is likely...

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PMID: 28160495
DOI: 10.1002/jcp.25843

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