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Article

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.

Journal of neuroinflammation - 2 Apr 2012

Ferretti Maria Teresa, Allard Simon, Partridge Vanessa, Ducatenzeiler Adriana, Cuello A Claudio

Abstract excerpt

BACKGROUND: A growing body of evidence indicates that inflammation is one of the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown the occurrence of an early, pro-inflammatory reaction in the hippocampus of young, three-month-old transgenic McGill-Thy1-APP mice in the absence of amyloid plaques but associated with intracellular accumulation of amyloid beta petide...

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Share to Amyloid Neuropathies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22472085
DOI: 10.1186/1742-2094-9-62
PMCID: PMC3352127

Genes

APP

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