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Article

Death of neuronal clusters contributes to variance of age at onset in Huntington's disease.

Neurogenetics - 1 Mar 2006

Cajavec Branka, Herzel Hanspeter, Bernard Samuel

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disease caused by an expanded polyglutamine (polyQ) repeat in the protein huntingtin. Due to selective neuronal loss in the cortex and striatum, HD patients develop various movement disturbances, psychological changes, and dementia. Symptoms usually appear in individuals between 30 and 50 years of age. The principal cause of variability of age at onset (AO)...

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Identifiers

PMID: 16416264
DOI: 10.1007/s10048-005-0025-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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